Pathophysiological Roles of ASK1-MAP Kinase Signaling Pathways
نویسندگان
چکیده
منابع مشابه
Map kinase signaling pathways and hematologic malignancies.
Mitogen-activated protein (Map) kinases are widely expressed serine-threonine kinases that mediate important regulatory signals in the cell. Three major groups of Map kinases exist: the p38 Map kinase family, the extracellular signal-regulated kinase (Erk) family, and the c-Jun NH2-terminal kinase (JNK) family. The members of the different Map kinase groups participate in the generation of vari...
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The mammalian mitogen-activated protein (MAP) kinase kinase kinase apoptosis signal-regulating kinase 1 (ASK1) is a pivotal component in cytokine- and stress-induced apoptosis. It also regulates cell differentiation and survival through p38 MAP kinase activation. Here we show that Ca2+ signalling regulates the ASK1-p38 MAP kinase cascade. Ca2+ influx evoked by membrane depolarization in primary...
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Mitogen-activated protein kinase (MAPK) pathways regulate diverse processes ranging from proliferation and differentiation to apoptosis. Activated by an enormous array of stimuli, they phosphorylate numerous proteins, including transcription factors, cytoskeletal proteins, kinases and other enzymes, and greatly influence gene expression, metabolism, cell division, cell morphology and cell survi...
متن کاملMAP kinase pathways.
Mitogen-activated protein kinase (MAPK) modules containing three sequentially activated protein kinases are key components of a series of vital signal transduction pathways that regulate processes such as cell proliferation, cell differentiation, and cell death in eukaryotes from yeast to humans (Fig. 1) (Qi and Elion 2005; Raman et al. 2007; Keshet and Seger 2010). Each cascade is initiated by...
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ژورنال
عنوان ژورنال: BMB Reports
سال: 2007
ISSN: 1976-6696
DOI: 10.5483/bmbrep.2007.40.1.001